B&O American Brasserie is located in the landmark old B&O Railroad Building, adjacent to Hotel Monaco Baltimore at 2 North Charles Street. It's the history-rich end of Charles Street in downtown Baltimore. The Charles Center Metro is literally just across West Baltimore Street, and the Baltimore St. & Charles St. bus stop is on the corner opposite Hotel Monaco. For subway and bus schedules, please visit the Maryland Transit Authority website.
B&O is brief walk from the Baltimore Convention Center, the University of Maryland and Oriole Park at Camden Yards.